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KMID : 1123920090230051132
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Korean Journal of Oriental Physiology and Pathology
2009 Volume.23 No. 5 p.1132 ~ p.1138
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Inhibitory Effect of WK-38 on TNF-α Induced Vascular Inflammation in Human Umbilical Vein Endothelial Cells
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Hwang Sun-Mi
Lee Yun-Jung
Kim Eun-Ju
Yoon Jung-Joo
Lee Hyeok
Kang Dae-Gil
Lee Ho-Sub
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Abstract
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Vascular inflammation is an important event in the development of vascular diseases such as tumor progression and atherosclerosis. This study was to investigate the inhibitory effects of WK-38, a new herbal prescription for the treatment of atherosclerosis, on vascular inflammation in human umbilical vein endothelial cells (HUVEC). WK-38 is composed of Rhei Rhizoma, Magonoliae Cortex, Moutan Cortex Radicis. Pretreatment with WK-38 was significantly blocked TNF-α-induced expression level of cell adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1), intracellular adhesion molecule-1 (ICAM-1), and endothelial cell selectin (E-selectin) in a dose-dependent manner. TNF-α-induced cell adhesion in co-cultured U937 and HUVEC was also blocked by pretreatment with WK-38. Moreover, WK-38 significantly suppressed p65 NF-κB translocation into the nucleus by TNF-α as well as the phosphorylation and degradation of IκB-α. In conclusion, the present data suggested that WK-38 could suppress TNF-α-induced vascular inflammatory process, though inhibition of NF-κB activation in HUVEC.
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KEYWORD
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WK-38, atherosclerosis, CAMs, NF-κB, IκB-α
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